I've done drivers side front and rear doors so far and it hasn't been too difficult, it can be done by one person.
I'm astounded by how much detail has been put into the door cards, they have loads of self adhesive foam seals, places routed especially for wiring and each door seems to be hand numbered.
It takes a few attempts to align the window frames perfectly so that the door opens and closes correctly and seals.
The door seals themselves seem to be made out of very high quality rubber and all the little channels and clips it all fits into is just right.. My 21 plate Toyota seals look far worse than 20 year old audi ones.
Also there are different types of sound deadning material in the front and rear as if they properly experimented with what shape/size/material works best.
I haven't broken any door card clips yet