I would imagine a bearing worn enough to do that would result in some pretty substantial vibrations through the car? They've never been a particularly strong point of design on Audis - I've always treated the seals as consumables on age grounds when they've gone. I seem to recall now that I've needed more of them doing on our old A6 than the S8, although the mechanicals are pretty much identical in running gear terms.
The bearing for the right side appears to be integral to the differential, so is a pretty meaty piece of kit and I suspect involves a full refurb of the diff to change, as a new bearing would require different shimming. There may be one on the left side which forms part of the speedometer drive, according to ElsaWin, but wear in that bearing shouldn't cause a problem with the oil seal as the bearing is between the output flange and the shaft.
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===SOLD===2002 Audi S8 D2 Final Edition (yes, really) in Avus Silver with purple extended leather===SOLD===
2011 S5 Sportback in Phantom Black with black Super Sports leather, 9x20s, tech pack high, adaptive xenon plus, intelligent key, memory seats pack, sunroof, B&O, Audi Drive Select & quattro Sports Diff, DAB, parking system plus
2015 VW Golf GTI Performance Pack in Carbon Grey with black Vienna leather, tech pack (Discovery Pro nav & Dynaudio), DCC, factory towbar and retrofit RVC
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