The W12 has Flaps in the exhaust system from the factory but there there as a relief system for excess back pressure when you give the 6.0L a led foot rather than a sound enhancer.
wheel wise the discs are 390mm and the same spec as the non ceramic S8 brakes and i know there are many 18" wheels that do fit over the brakes
http://forum.a8parts.co.uk/showthread.php?t=5567
and the QS Wheels share the same Off set so i dont see any reason why they would not fit
just have a nice chunky profile on them like a 50 or 55 and winter tyres and there will be no where you cant go